In fact, a few studies suggest that the appendix plays an immunological role, and helps maintain the balance of microbial flora in the gut. Being rich in active lymphatic follicles and immunoglobulin (Ig)A- and IgG-producing immunocytes, its tissue might help protect against infection. However, problems can arise, if it becomes inflamed. Inflammation of appendix, which is medically referred to as appendicitis, is a serious condition that could turn life-threatening, if the appendix ruptures.