➜ If the underlying cause is not identifiable or cannot be treated, then surgical treatment of the spleen may be required. Even in case of chronic or critical cases, surgical intervention might be an option. In some cases, the patient does not respond to treatment and is dependent on transfusion. In such cases, a part or the complete spleen has to be removed. However, spleen removal does not treat the problem totally, but it reduces the incidence of low white blood cell count.