☞Abnormal Thyroid Function
Another major cause is abnormal functioning of the thyroid gland. Under activity, i.e., decrease in the production of the hormone thyroxine leads to hypothyroidism. Fatigue, weakness, depression, constipation, etc. are the symptoms of hypothyroidism. On the other hand, increase in the level of thyroxine, i.e., hyperthyroidism also leads to fatigue in muscles.