In diabetes, the glucose does not enter the cells. This can be either due to insulin insufficiency or body cells not being receptive to actions of insulin. In any case, cell absorption of glucose does not take place. A small amount of glucose is always present in the bloodstream. However, as body cells are unable to absorb glucose, it leads to pooling of glucose in the bloodstream. So, despite high amount of glucose circulating in the bloodstream, body cells are deprived of it.The cellular response to glucose starvation manifests in the form of frequent hunger pangs.